⬡ Clinical Trials & Studies

Association between mental health symptoms and autoimmunity in patients with long COVID.

Pro-inflammatory diet and the risk of depression and anxiety: A prospective study based on the dietary inflammatory index.

Transcultural prediction model for late-life depression based on multi-cohort machine learning and explainable AI.

Association Between the Serum Creatinine to Cystatin C Ratio and Cardiovascular Disease in Middle-Aged and Older Adults in China: A Nationwide Cohort Study.

European Study of Prostate Cancer Screening - 23-Year Follow-up.

Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950-2023: a demographic analysis for the Global Burden of Disease Study 2023.

Mendelian randomization study of sleep traits and risk of colorectal cancer.

Effect of Esketamine on Depressive Symptoms in Adolescents With Major Depressive Disorder at Imminent Suicide Risk: A Randomized Psychoactive-Controlled Study.

Risks of All-Cause Mortality in Adults With Chronic Kidney Disease With Sarcopenia or Obesity: A Population-Based Study.

High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.

Rise and Fall of Physical Capacity in a General Population: A 47-Year Longitudinal Study.

Center- vs Home-Based Cardiac Rehabilitation in Patients With Heart Failure: EXIT-HF Randomized Controlled Trial.

Running from Death: Can Fitness Outpace Alcohol's Harm? Changes in Alcohol Intake, Fitness and All-Cause Mortality in the HUNT Study, Norway.

Cluster sets and traditional sets elicit similar muscular hypertrophy: a volume and effort-matched study in resistance-trained individuals.

Lifestyle changes beating sleep studies for some men

Community members report that quitting alcohol, consistent exercise, and walking 10k steps daily resolved sleep issues within weeks without medical intervention. This signals men prefer actionable self-directed solutions over clinical pathways when possible.

Younger men with low T seeking validation before urologist appointments

Men in their early 30s with below-range testosterone are turning to Reddit communities for reassurance and real-world experiences before medical consultations, indicating distrust or uncertainty about clinical guidance alone.

Estrogen management and dosing frustrations plague early TRT users

Newer TRT users report struggling with dialing in dosages, with high estrogen side effects at higher doses causing regret and second-guessing. The trial-and-error process in the first months creates negative experiences that may lead to dropout.

Long-term TRT users report sustained life-changing benefits over years

Men with 4-10+ years on TRT consistently describe transformative improvements in body composition, energy, and quality of life. This positive sentiment from experienced users may influence newer patients considering long-term commitment to therapy.

Southern U.S. male life expectancy stalled since 1950

Yale study reveals men in Southern states gained less than two years of life expectancy after 1950, while Hawaii and Massachusetts show continued improvement.

TRT validated for healthspan improvement in 2025 research

Emerging studies confirm testosterone replacement therapy improves muscle mass, bone density, and metabolic health in those with clinically low testosterone.

Men with no mental health history show higher suicide completion rates

A 2022 study cited by BMC HealthCity found suicide rates were much higher among men without diagnosed mental illness, indicating critical gaps in early detection and diagnosis frameworks.

Bedtime screen use effects vary by sex and demographics

A major Canadian study found the relationship between bedtime screen use and sleep health varies by biological sex, age, and income, suggesting one-size-fits-all screen guidance may be insufficient for men's sleep interventions.

40% of men under 40 interested in testosterone supplementation

US Pharmacist reports significant interest in TRT among younger men, with 14% having used testosterone products. This demonstrates growing demand that may outpace evidence-based clinical indications.